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DOXADENT pressrelease

Press Release Uppsala 16th Oct. 2002

Breakthrough for the Bionic Man

New Swedish biomaterial integrates with human tissue

Background:
In October 2000, the new directly applicable ceramic dental material, DoxaDent, was launched, a material that needs no cement for its application, which gave new hope to many sensitive patients world-wide. Information was published in the Heavy Metal Bulletins No. 2 & 3, 2000. Now a group of Swedish researchers, including those behind DoxaDent have produced a completely new biomaterial with unique properties. The new material integrates with bone tissue so that no join is visible even down at atom level. Sounds almost too good to be true…See press release below.

A group of Swedish researchers have produced a completely new biomaterial with unique properties.
Tests show that the new material integrates with bone tissue so that no join is visible even down at atom level.
”This is one of the most important advances since it was discovered that the human body will accept titanium implants,” comments Professor Peter Thomsen of the Department of Biomaterial Science, Sahlgrenska Academy at Gothenburg University.

Many parts of the body can be replaced or substituted by artificial components made of biomaterials. At present this is done using metals, various plastics, bioceramics and similar materials.

The major difficulty up to now has been getting the body to accept implants and above all, to get them to stay firmly in position. However, five months ago, a team of researchers at Doxa AB led by Professor Leif Hermansson found the unique solution. Their discovery involves total integration of the biomaterial with bone tissue – an integration taking place directly in the body.

Historic Discovery

”This is a historic discovery with enormous potential. For instance, the technique lends itself naturally to dental restoration, where the composites in use today can shrink after a while, resulting in secondary caries. The new material cannot shrink or cause a gap against the tooth wall because it integrates with the tooth,” adds Professor Peter Thomsen.

”Odontology, orthopaedics and plastic surgery are areas where this technology can usefully be applied. In cases of osteoporosis or fractures, the innovative technique can help produce new bone which is much stronger than using any currently available materials. Furthermore, patients suffering from rheumatism or cancer causing orthopaedic implications, will also benefit from the technique,” Lars Magnus Bjursten concludes, Professor of Bio-implant Research at Lund University.

Doxa’s discovery is a directly applied ceramic material known as the ”CAH-HAP system,” CAH referring to calcium-aluminate and HAP to hydroxyl-apatite, the mineral found in bone.

The unique reaction takes place when calcium-aluminate interacts with body fluid or water containing phosphate to form the body’s own ceramic – apatite. All the fluid enveloping the calcium-aluminate is used up in the reaction resulting in all the water-filled areas being replaced by solid material. In consequence, a compact body is formed, making it impossible to discern any boundary between bone tissue and the implant.

The new ceramic material has numerous positive properties. It is very durable and chemically stabile. It displays thermic properties similar to those of cortical tissue, is both biocompatible and environmentally friendly. The ceramic is also easy to form and work with, and is formed directly in situ in the body at normal body temperatures.

Peter Bramberg, CEO Doxa

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